At The Retina Clinic London, we understand the complex medical journeys many of our patients face, especially those undergoing tamoxifen therapy for various conditions. Our Tamoxifen Screening Service is designed to provide comprehensive monitoring and support for individuals undergoing tamoxifen therapy, ensuring that any signs of toxicity in the retina from the drug are picked up as soon as possible and managed to prevent any long-term harm.
What is tamoxifen?
Tamoxifen is a medication with many applications, primarily known for its use in breast cancer treatment. However, it is also utilized in the management and prevention of other conditions, such as certain types of breast cancer risk reduction, infertility treatments, and gynecomastia treatment in men. The usual low dose of 20-40mg should not cause profound ocular side effects, historically found in doses of 150+mg per day.
How can tamoxifen affect the retina?
While tamoxifen can offer significant benefits in medical management, it’s not without potential risks. One of the recognized side effects of tamoxifen therapy is retinal toxicity, specifically known as tamoxifen retinopathy. This condition can manifest as various changes in the retina, including retinal pigment epithelium (RPE) alterations, crystalline deposits, macular edema, and even retinal detachment in severe cases.
How often should I undergo screening when undergoing tamoxifen therapy?
Patients undergoing tamoxifen therapy should undergo regular ocular screenings to monitor for signs of retinal toxicity. The frequency of screenings should be every 4-6 months initially and increased to every 3 months if ocular side effects occur. The risk for toxicity is generally considered to be greater than 5mg/kg per day of tamoxifen. Additionally, patients should be aware of the risk of cataract formation and Meibomian gland dysfunction associated with tamoxifen therapy.
What does our private tamoxifen retinopathy screening include?
Our Tamoxifen Screening Service employs a comprehensive screening protocol to evaluate ocular health and detect early signs of retinal toxicity. The screening includes:
| Features | The Retina Clinic London Tamoxifen Screening Service |
|---|---|
| Expertise | Our clinic boasts a team of highly specialized retinal specialists led by Professor Paulo Eduardo Stanga with extensive experience in tamoxifen-related retinal toxicity. |
| Screening Technologies | • Optical Coherence Tomography (OCT): This imaging modality provides high-resolution, cross-sectional images of the retina, allowing for the detection of subtle structural changes indicative of retinal toxicity. • Microperimetry: Functional testing method used to assess retinal sensitivity and fixation stability, aiding in the detection of functional changes associated with tamoxifen toxicity. • Adaptive Optics Imaging: Advanced imaging technique providing high-resolution images of individual photoreceptor cells and microscopic retinal structures, enabling precise monitoring and early detection of retinal changes not visible with conventional imaging modalities. |
| Personalised Care | Our approach to screening is highly individualized, with a focus on understanding each patient's unique medical history, concerns, and goals. We tailor our screening protocols and treatment plans to meet the specific needs of each individual. |
| Appointment Efficiency | We prioritize prompt appointments and efficient follow-up care to ensure timely screenings and interventions as needed. Our clinic administrators are always on head to ensure that, patients are able to access care when they need it most. |
| Focus | Our clinic specialises in detecting and managing tamoxifen-related retinal toxicity, with a dedicated focus on providing comprehensive care and support to patients undergoing tamoxifen therapy. |
| Screening Frequency | We recommend screenings every 4-6 months initially, with the frequency increasing to every 3 months if ocular side effects occur or as indicated based on individual patient needs. Prof. Stanga and his team will be able to advise on the recommended frequency of follow-up screenings and consultations depending on the results of your previous screening. |
| Patient Education | We provide thorough patient education on tamoxifen-related retinal toxicity, screening processes, and treatment options. Our goal is to empower patients with the knowledge and resources they need to make informed decisions about their eye health. |
What options are there available to book a screening
When booking in for screening appointments at The Retina Clinic London, there are always two options available with regards to care:
Full screening with Optometrist:
This appointment includes the full screening service with a report produced at the end and sent to you. This report will note all the findings from the screening and include a recommended plan for when to come in for further screenings.
Please note that this does not include a consultation with Prof. Stanga or a member of his medical team to undergo a full vitreoretinal examination alongside the discussion of results.
The cost of this appointment option is £650
Full Screening with consultation with Prof. Stanga/member of his medical team:
This appointment includes the full screening and then a full 45-minute consultation with Professor Stanga or a member of his medical team to discuss the results, any important outcomes, perform a further full vitreoretinal examination, and to formulate a plan of any treatment required alongside any follow-ups.
The cost of this appointment option is £950.
